eISSN: 1897-4317
ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
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abstract:
Original paper

Consumption of proton pump inhibitors in outpatients of Gastroenterology Clinics in Khyber Pakhtunkhwa: evidence of inexpedient use

Muhammad Ashfaq
1
,
Syed Mobasher Ali Abid
1
,
Qasim Khan
1
,
Muhammad Junaid Hassan Sharif
1
,
Muhammad Zeeshan Haroon
2
,
Adil Naseer Khan
3
,
Yasser MSA Alkahraman
1

  1. Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Pakistan
  2. Department of Community Medicine, Ayub Medical College, Abbottabad, Pakistan
  3. Department Gastroenterology, MTI, Ayub Teaching Hospital, Abbottabad, Pakistan
Gastroenterology Rev
DOI: https://doi.org/10.5114/pg.2024.139429
Online publish date: 2024/05/08
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Introduction
Proton pump inhibitors (PPIs) are effective drugs used for multiple gastrointestinal complications. They are commonly used in both hospitalised and outpatients. However, little is known about its utilisation pattern in ambulatory patients.

Aim
To evaluate the inexpedient continuous use of PPIs in patients with respect to treatment duration.

Material and methods
A cross-sectional observational study was conducted from January 2018 to November 2019 in Khyber Pakhtunkhwa, Pakistan. Regular proton pump inhibitor users were identified through patient histories.

Results
During the study period, 171 patients were included using a non-probability consecutive sampling technique, who were using regular proton pump inhibitors for a longer duration, i.e. from 3 months to 15 years. The highest proportion (42.8%) were using PPI regularly from 3 months to 1 year followed by 22.9% for 1–2 years, 12.0% for 2–3 years, 7.8% for 3–4 years, 4.2% for 4–5 years, and 10.24% for > 5 years. Omeprazole and esomeprazole were the most commonly used drugs, with 71.1% and 23.5% prevalence, respectively. A total of 33.73% of patients had continued PPI use on their own after initially being prescribed by the physician.

Conclusions
It can be deduced that PPIs are used in outpatients beyond standard treatment guidelines. The inexpedient continuous use of proton pump inhibitors is of concern due to the risk of developing adverse effects. Therefore, patient counselling and periodic monitoring must be carried out to prevent the irrational use of PPIs.

keywords:

irrational use, inexpedient use, long-term therapy, proton pump inhibitors, treatment duration
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